Zoe, 48, and David, 47, went to thank rock band Keane after the group performed their smash hit Somewhere Only We Know, before handing over the reins to Alesha Dixon, 40, and comedian Romesh Ranganathan, 4, who would be presenting the third hour of the BBC telethon.
True to form, Zoe and David had to give the current total of the Comic Relief fundraising efforts before making their exit from the stage.
Standing next to Keane vocalist Tom Chaplin, 40, Zoe announced the total and was ecstatic to see how much money had been raised for Comic Relief.
However, as her emotions took over, Zoe grabbed hold of the singer and hugged him tight as David celebrated on the other side of the stage.
Following the musical performance, Zoe and David applauded the band, with the Strictly spin-off show host saying: “Absolutely amazing.
“Now, it’s the moment all hosts at this time look forward to. It is time to find out how much we’ve already raised together so far, Zoe continued.
Ahead of revealing the total, Zoe told the audience: “Let’s see what your generous donations have added to the total.”
Taking over, David revealed the total, with Zoe screaming in excitement behind him and clapping her hands, as she pulled him in exclaiming: “Come on, Tom.”
Tom burst into laughter after Zoe’s action, as the host then remarked “Sorry,” to the vocalist, with the Keane band member saying: “That’s alright.”
After her apology, Zoe went back to addressing the audience, telling them: “That is a huge amount of money, we can not thank you enough for your generosity.”
However, Zoe’s reaction to the fundraiser total wasn’t the only moment of humour a host experienced during the telethon.
As the pair revealed what was coming up throughout the course of the telethon, Emma got overly exited by an upcoming performance from the cast of Magic Mike Live.
With Paddy trying to tell viewers at home what sketches and performances were coming up on the show, Emma interjected on several occasions to mention the routine by the half-naked male dancers.
Jokingly frustrated with his co-host, Paddy warned Emma: “You need to rein it in Willis, this is a a family show,” after the presenter’s third mention of the Magic Mike performance.
Paddy proceeded to ask the studio audience: “Ladies out there, you don’t want to see a load of half-naked men gyrating on the stage, do ya?”
The audience cheered in support of Emma’s excitement, with Paddy adding: “They do,” following his question.
As the show got underway, the sketches continued to flow, with the sequel to Four Weddings And A Funeral, as well as a comedic spoof of musical movie, Mamma Mia Here We Go Again!
However, viewers were divided over the Jennifer Saunders led sketch, which saw the comedian take on the roles of both Meryl Streep’s character and Cher’s.
Comic Relief patron Lenny Henry, 60, also paid tribute to former One Direction star Louis Tomlinson, 27, who cancelled his appearance on the show following the death of his sister Felicitie Tomlinson.
Comic Relief 2019 airs tonight on BBC One.